Nexium vs Losec

A side-by-side look at two gastrointestinal medications advertised on TV. Informational only — not medical advice.

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Information reviewed July 24, 2026

NZ NexiumNZ Losec
Generic nameesomeprazoleomeprazole
Drug classProton Pump Inhibitor (PPI)Proton Pump Inhibitor (PPI)
TreatsAcid reflux, GERD, stomach ulcersAcid reflux, stomach ulcers, GERD
CategoryGastrointestinalGastrointestinal
ManufacturerAstraZenecaAstraZeneca
Year approved20001989
FDA warningNo boxed warningNo boxed warning
Est. TV ad spend$6M$3M
Common side effectsHeadache, Diarrhea, Nausea, Abdominal painHeadache, Diarrhea, Stomach pain, Nausea

Frequently asked questions

Is Nexium or Losec better?

Neither is universally "better." Nexium (esomeprazole) and Losec (omeprazole) are both used for gastrointestinal, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.

What's the difference between Nexium and Losec?

Nexium is a Proton Pump Inhibitor (PPI) made by AstraZeneca, while Losec is a Proton Pump Inhibitor (PPI) made by AstraZeneca. See the table above for a side-by-side breakdown.

Which one spends more on TV ads?

Nexium has the larger estimated TV advertising budget of the two.

TVPills

A reference tool to help identify prescription medications and supplements seen in television advertising. This is not medical advice. Always consult a healthcare professional.

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