Rexulti vs Vyvanse
A side-by-side look at two mental health medications advertised on TV. Informational only — not medical advice.
| US Rexulti | US Vyvanse | |
|---|---|---|
| Generic name | brexpiprazole | lisdexamfetamine |
| Drug class | Atypical Antipsychotic | CNS Stimulant |
| Treats | Major depression (add-on), schizophrenia, agitation in dementia | ADHD, binge eating disorder |
| Category | Mental Health | Mental Health |
| Manufacturer | Otsuka/Lundbeck | Takeda |
| Year approved | 2015 | 2007 |
| FDA warning | Black box warning | Black box warning |
| Est. TV ad spend | $170M | $70M |
| Common side effects | Weight gain, Restlessness, Drowsiness, Movement disorders | Decreased appetite, Insomnia, Dry mouth, Increased heart rate |
Frequently asked questions
Is Rexulti or Vyvanse better?
Neither is universally "better." Rexulti (brexpiprazole) and Vyvanse (lisdexamfetamine) are both used for mental health, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.
What's the difference between Rexulti and Vyvanse?
Rexulti is a Atypical Antipsychotic made by Otsuka/Lundbeck, while Vyvanse is a CNS Stimulant made by Takeda. See the table above for a side-by-side breakdown.
Which one spends more on TV ads?
Rexulti has the larger estimated TV advertising budget of the two.