Rinvoq vs Otezla

A side-by-side look at two autoimmune medications advertised on TV. Informational only — not medical advice.

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Information reviewed July 24, 2026

US RinvoqUS Otezla
Generic nameupadacitinibapremilast
Drug classJAK InhibitorPDE4 Inhibitor
TreatsRheumatoid arthritis, psoriatic arthritis, eczemaPlaque psoriasis, psoriatic arthritis, Behçet's disease
CategoryAutoimmuneAutoimmune
ManufacturerAbbVieAmgen
Year approved20192014
FDA warningBlack box warningNo boxed warning
Est. TV ad spend$175M$110M
Common side effectsSerious infections, Blood clots, Cardiovascular events, Cancer riskDiarrhea, Nausea, Headache, Weight loss

Frequently asked questions

Is Rinvoq or Otezla better?

Neither is universally "better." Rinvoq (upadacitinib) and Otezla (apremilast) are both used for autoimmune, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.

What's the difference between Rinvoq and Otezla?

Rinvoq is a JAK Inhibitor made by AbbVie, while Otezla is a PDE4 Inhibitor made by Amgen. See the table above for a side-by-side breakdown.

Which one spends more on TV ads?

Rinvoq has the larger estimated TV advertising budget of the two.

TVPills

A reference tool to help identify prescription medications and supplements seen in television advertising. This is not medical advice. Always consult a healthcare professional.

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