Trulance vs Motegrity
A side-by-side look at two gastrointestinal medications advertised on TV. Informational only — not medical advice.
| US Trulance | US Motegrity | |
|---|---|---|
| Generic name | plecanatide | prucalopride |
| Drug class | Guanylate Cyclase-C Agonist | Serotonin-4 Receptor Agonist |
| Treats | Chronic constipation and IBS-C | Chronic idiopathic constipation |
| Category | Gastrointestinal | Gastrointestinal |
| Manufacturer | Salix (Bausch Health) | Takeda |
| Year approved | 2017 | 2018 |
| FDA warning | Black box warning | Moderate warnings |
| Est. TV ad spend | — | — |
| Common side effects | Diarrhea, Should not be used in young children (boxed warning), Abdominal pain, Bloating | Headache, Abdominal pain, Nausea, Diarrhea |
Motegrity
Frequently asked questions
Is Trulance or Motegrity better?
Neither is universally "better." Trulance (plecanatide) and Motegrity (prucalopride) are both used for gastrointestinal, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.
What's the difference between Trulance and Motegrity?
Trulance is a Guanylate Cyclase-C Agonist made by Salix (Bausch Health), while Motegrity is a Serotonin-4 Receptor Agonist made by Takeda. See the table above for a side-by-side breakdown.
Which one spends more on TV ads?
Trulance has the larger estimated TV advertising budget of the two.