Verzenio vs Calquence

A side-by-side look at two oncology medications advertised on TV. Informational only — not medical advice.

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Information reviewed July 24, 2026

US VerzenioUS Calquence
Generic nameabemaciclibacalabrutinib
Drug classCDK4/6 InhibitorBTK Inhibitor
TreatsHR+/HER2- breast cancerChronic lymphocytic leukemia and mantle cell lymphoma
CategoryOncologyOncology
ManufacturerEli LillyAstraZeneca
Year approved20172017
FDA warningModerate warningsModerate warnings
Est. TV ad spend$85M
Common side effectsDiarrhea, Low blood counts, Fatigue, Blood clotsHeadache, Diarrhea, Bruising and bleeding, Infections

Frequently asked questions

Is Verzenio or Calquence better?

Neither is universally "better." Verzenio (abemaciclib) and Calquence (acalabrutinib) are both used for oncology, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.

What's the difference between Verzenio and Calquence?

Verzenio is a CDK4/6 Inhibitor made by Eli Lilly, while Calquence is a BTK Inhibitor made by AstraZeneca. See the table above for a side-by-side breakdown.

Which one spends more on TV ads?

Verzenio has the larger estimated TV advertising budget of the two.

TVPills

A reference tool to help identify prescription medications and supplements seen in television advertising. This is not medical advice. Always consult a healthcare professional.

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