Otezla Side Effects
Common and serious side effects of Otezla (apremilast), what to watch for, and when to call your doctor.
Common side effects
This is not a complete list. Always consult a doctor or pharmacist.
- Diarrhea
- Nausea
- Headache
- Weight loss
- Depression
- Upper respiratory infection
Serious warnings
Otezla does not carry an FDA Boxed Warning, but every prescription medicine has risks and possible interactions. Always follow your doctor's instructions and read the medication guide that comes with it.
When to call a doctor
As a general rule with any prescription medicine, contact your doctor about any side effect that is severe, persistent, or worries you. General guidance is to seek emergency care for signs of a serious allergic reaction to any medicine — such as trouble breathing or swelling of the face, lips, tongue, or throat.
The “Talk to a doctor” buttons are affiliate links to our telehealth partners Sesame and Lyla Health. TVPills may earn a commission. This is not medical advice.
Other Autoimmune medications
Compare Otezla with other autoimmune drugs advertised on TV.
Frequently asked questions
What are the most common side effects of Otezla?
Commonly reported side effects of Otezla (apremilast) include Diarrhea, Nausea, Headache, Weight loss, Depression, and Upper respiratory infection. This is not a complete list — tell your doctor or pharmacist about any side effects you experience.
Does Otezla have any serious or boxed warnings?
Otezla does not carry an FDA Boxed Warning, but every prescription medicine has risks and possible interactions. Always follow your doctor's instructions and read the medication guide that comes with it.
When should I call my doctor about Otezla side effects?
As a general rule with any prescription medicine, call your doctor about any side effect that is severe, doesn't go away, or worries you. General guidance is to seek emergency care for signs of a serious allergic reaction to any medicine — such as trouble breathing or swelling of the face, lips, tongue, or throat. For advice about your situation, talk to a licensed healthcare provider.
Where can I find the full list of Otezla side effects?
The side effects above are commonly reported ones recorded for Otezla (apremilast); they are not a complete list. For the full prescribing information and medication guide, check the official Otezla label or ask your doctor or pharmacist.
Should I stop taking Otezla if I have side effects?
General medical guidance is not to stop a prescription medicine on your own without talking to your doctor first. Your doctor can advise whether to continue, adjust, or change your treatment. This page is informational and not medical advice.