Auvelity vs Spravato
A side-by-side look at two mental health medications advertised on TV. Informational only — not medical advice.
Maintained by TVPills Editorial Team · Site updated November 4, 2026 (not a product-label review)
| Attribute | US Auvelity | US Spravato |
|---|---|---|
| Generic name | dextromethorphan/bupropion Unverified catalogue summary (Generic name) for Auvelity in US; not checked against current local product information. | esketamine Unverified catalogue summary (Generic name) for Spravato in US; not checked against current local product information. |
| Drug class | See official local label Unverified catalogue summary (Drug class) for Auvelity in US; not checked against current local product information. | See official local label Unverified catalogue summary (Drug class) for Spravato in US; not checked against current local product information. |
| Treats | Major depressive disorder in adults; agitation associated with dementia due to Alzheimer's disease Unverified catalogue summary (Treats) for Auvelity in US; not checked against current local product information. | Treatment-resistant depression Unverified catalogue summary (Treats) for Spravato in US; not checked against current local product information. |
| Category | Mental Health Unverified catalogue summary (Category) for Auvelity in US; not checked against current local product information. | Mental Health Unverified catalogue summary (Category) for Spravato in US; not checked against current local product information. |
| Manufacturer | Axsome Therapeutics Unverified catalogue summary (Manufacturer) for Auvelity in US; not checked against current local product information. | Janssen Unverified catalogue summary (Manufacturer) for Spravato in US; not checked against current local product information. |
| Year approved | — Unverified catalogue summary (Year approved) for Auvelity in US; not checked against current local product information. | — Unverified catalogue summary (Year approved) for Spravato in US; not checked against current local product information. |
| Catalogue warning level | Safety summary withheld — check official label Unverified catalogue summary (Catalogue warning level) for Auvelity in US; not checked against current local product information. | Safety summary withheld — check official label Unverified catalogue summary (Catalogue warning level) for Spravato in US; not checked against current local product information. |
| Est. TV ad spend | $50M | — |
| Side effects and serious risks | — Unverified catalogue summary (Side effects and serious risks) for Auvelity in US; not checked against current local product information. | — Unverified catalogue summary (Side effects and serious risks) for Spravato in US; not checked against current local product information. |
Sources and editorial standards
Use the current DailyMed labels to verify approved uses, boxed warnings, and side effects for each medication. Label results can differ by product, strength, and formulation.
Page updated November 4, 2026; the linked resources have not necessarily been reviewed on this date.
Frequently asked questions
Is Auvelity or Spravato better?
This directory does not compare clinical effectiveness or safety. Listing Auvelity and Spravato together does not establish shared approved indications, equivalence or suitability as substitutes. Consult the correct local labels and your prescriber.
What's the difference between Auvelity and Spravato?
The table shows catalogue identification and estimated advertising information for Auvelity and Spravato, not a verified medical comparison. Medical descriptions, mechanisms and safety summaries are withheld.
Which one spends more on TV ads?
Auvelity has the larger estimated TV advertising budget of the two.