Spravato Alternatives

Drugs like Spravato (esketamine) — other mental health medications advertised on TV that may be alternatives. Informational only — not medical advice. Only your doctor can decide what's right for you.

Unverified catalogue summary (alternative grouping) for Spravato in US; not checked against current local product information.

Vraylar

cariprazine · Forest Laboratories Ireland Limited

Treats Schizophrenia (age 13+), bipolar I mania/mixed episodes (age 10+), adult bipolar I depression, adult MDD (add-on)

Unverified catalogue summary (alternative identity, manufacturer and indication) for Vraylar in US; not checked against current local product information.

Details vs Spravato Cost

Rexulti

brexpiprazole · Otsuka Pharmaceutical Co., Ltd.

Treats Adult major depression (add-on), schizophrenia (age 13+), agitation associated with dementia due to Alzheimer's disease

Unverified catalogue summary (alternative identity, manufacturer and indication) for Rexulti in US; not checked against current local product information.

Details vs Spravato Cost

Caplyta

lumateperone · Intra-Cellular Therapies, Inc. (US distributor)

Treats Adult schizophrenia, bipolar I/II depression, major depression (add-on)

Unverified catalogue summary (alternative identity, manufacturer and indication) for Caplyta in US; not checked against current local product information.

Details vs Spravato Cost

Trintellix

vortioxetine · Takeda Pharmaceuticals America, Inc. (US marketer; licensed from H. Lundbeck A/S)

Treats Major depressive disorder

Unverified catalogue summary (alternative identity, manufacturer and indication) for Trintellix in US; not checked against current local product information.

Details vs Spravato Cost

Latuda

lurasidone · Sumitomo Pharma America, Inc.

Treats Schizophrenia and depressive episodes associated with bipolar I disorder

Unverified catalogue summary (alternative identity, manufacturer and indication) for Latuda in US; not checked against current local product information.

Details vs Spravato Cost

Vyvanse

lisdexamfetamine · Takeda

Treats ADHD, binge eating disorder

Unverified catalogue summary (alternative identity, manufacturer and indication) for Vyvanse in US; not checked against current local product information.

Details vs Spravato Cost

Auvelity

dextromethorphan/bupropion · Axsome Therapeutics

Treats Major depressive disorder in adults; agitation associated with dementia due to Alzheimer's disease

Unverified catalogue summary (alternative identity, manufacturer and indication) for Auvelity in US; not checked against current local product information.

Details vs Spravato Cost

Adderall

amphetamine/dextroamphetamine · Teva Pharmaceuticals (manufactured for)

Treats ADHD, narcolepsy

Unverified catalogue summary (alternative identity, manufacturer and indication) for Adderall in US; not checked against current local product information.

Details vs Spravato Cost

Zoloft

sertraline · Viatris Specialty LLC (US distributor)

Treats Major depression, OCD, panic disorder, PTSD, social anxiety disorder, PMDD

Unverified catalogue summary (alternative identity, manufacturer and indication) for Zoloft in US; not checked against current local product information.

Details vs Spravato Cost

Abilify Maintena

aripiprazole · Otsuka

Treats Schizophrenia in adults and maintenance monotherapy of bipolar I disorder in adults

Unverified catalogue summary (alternative identity, manufacturer and indication) for Abilify Maintena in US; not checked against current local product information.

Details Cost

Nuplazid

pimavanserin · Acadia Pharmaceuticals

Treats Parkinson's disease psychosis

Unverified catalogue summary (alternative identity, manufacturer and indication) for Nuplazid in US; not checked against current local product information.

Details Cost

See all Mental Health medications

Sources and editorial standards

Product-label references, not clinical verification. Medicine identification—not prescribing guidance. This page does not provide a complete safety or dosing reference. Check the official label for your country and exact product, and consult your pharmacist or prescriber before starting, stopping or changing treatment. Missing information does not mean a medicine is safe for you. Reference formulation scope (not dosing instructions): esketamine nasal spray 28 mg per single-use device (two sprays), CIII; supervised intranasal administration

Unresolved / not established by these sources:

Clinical summaries, safety tiers and dosing guidance are withheld while their review remains unfinished.
A linked document may have been superseded. Confirm country, product, formulation and latest revision with the regulator or pharmacist.

US label reference: Spravato — current US full prescribing information (DailyMed SPL)
Manufacturer label · Reference scope: Reference link only. Verify the exact formulation and current revision; this does not certify a clinical summary.
US regulator product record (not a prescribing label): Spravato — FDA original NDA approval letter
Local licence · Reference scope: Reference link only. Verify the exact formulation and current revision; this does not certify a clinical summary.

Lookup resources (not product-specific citations; confirm formulation and country before use):

Frequently asked questions

What drugs are similar to Spravato?

Unverified catalogue grouping, not a clinically established substitute or a checked local indication. Drugs like Spravato include other mental health medications advertised on TV such as Vraylar, Rexulti, Caplyta and more. This is an editorial catalogue grouping, not a verified comparison of indications, safety or suitable substitutes. Ask your prescriber about treatment choices.

What can I take instead of Spravato?

Unverified catalogue grouping, not a clinically established substitute or a checked local indication. Other mental health medications advertised on TV include Vraylar, Rexulti, Caplyta and others. The right alternative depends on your diagnosis, medical history and insurance — only your doctor can recommend a substitute for Spravato. This page is informational only.

Is there a generic version of Spravato?

Unverified catalogue grouping, not a clinically established substitute or a checked local indication. Spravato is sold as esketamine. Whether a lower-cost generic is available depends on patent status — ask your pharmacist, and see the cost & savings page for ways to pay less.

Are these alternatives the same as Spravato?

Unverified catalogue grouping, not a clinically established substitute or a checked local indication. This catalogue grouping does not establish therapeutic equivalence, shared approved indications or suitability as a substitute. Do not switch medicines based on it; consult your prescriber.