Rexulti vs Trintellix
A side-by-side look at two mental health medications advertised on TV. Informational only — not medical advice.
| US Rexulti | US Trintellix | |
|---|---|---|
| Generic name | brexpiprazole | vortioxetine |
| Drug class | Atypical Antipsychotic | Serotonin Modulator (Antidepressant) |
| Treats | Major depression (add-on), schizophrenia, agitation in dementia | Major depressive disorder |
| Category | Mental Health | Mental Health |
| Manufacturer | Otsuka/Lundbeck | Takeda/Lundbeck |
| Year approved | 2015 | 2013 |
| FDA warning | Black box warning | Black box warning |
| Est. TV ad spend | $170M | $130M |
| Common side effects | Weight gain, Restlessness, Drowsiness, Movement disorders | Nausea, Sexual problems, Constipation, Vomiting |
Trintellix
Frequently asked questions
Is Rexulti or Trintellix better?
Neither is universally "better." Rexulti (brexpiprazole) and Trintellix (vortioxetine) are both used for mental health, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.
What's the difference between Rexulti and Trintellix?
Rexulti is a Atypical Antipsychotic made by Otsuka/Lundbeck, while Trintellix is a Serotonin Modulator (Antidepressant) made by Takeda/Lundbeck. See the table above for a side-by-side breakdown.
Which one spends more on TV ads?
Rexulti has the larger estimated TV advertising budget of the two.