Rexulti vs Trintellix
A side-by-side look at two mental health medications advertised on TV. Informational only — not medical advice.
Maintained by TVPills Editorial Team · Site updated November 4, 2026 (not a product-label review)
| Attribute | US Rexulti | US Trintellix |
|---|---|---|
| Generic name | brexpiprazole Unverified catalogue summary (Generic name) for Rexulti in US; not checked against current local product information. | vortioxetine Unverified catalogue summary (Generic name) for Trintellix in US; not checked against current local product information. |
| Drug class | See official local label Unverified catalogue summary (Drug class) for Rexulti in US; not checked against current local product information. | See official local label Unverified catalogue summary (Drug class) for Trintellix in US; not checked against current local product information. |
| Treats | Adult major depression (add-on), schizophrenia (age 13+), agitation associated with dementia due to Alzheimer's disease Unverified catalogue summary (Treats) for Rexulti in US; not checked against current local product information. | Major depressive disorder Unverified catalogue summary (Treats) for Trintellix in US; not checked against current local product information. |
| Category | Mental Health Unverified catalogue summary (Category) for Rexulti in US; not checked against current local product information. | Mental Health Unverified catalogue summary (Category) for Trintellix in US; not checked against current local product information. |
| Manufacturer | Otsuka Pharmaceutical Co., Ltd. Unverified catalogue summary (Manufacturer) for Rexulti in US; not checked against current local product information. | Takeda Pharmaceuticals America, Inc. (US marketer; licensed from H. Lundbeck A/S) Unverified catalogue summary (Manufacturer) for Trintellix in US; not checked against current local product information. |
| Year approved | — Unverified catalogue summary (Year approved) for Rexulti in US; not checked against current local product information. | — Unverified catalogue summary (Year approved) for Trintellix in US; not checked against current local product information. |
| Catalogue warning level | Safety summary withheld — check official label Unverified catalogue summary (Catalogue warning level) for Rexulti in US; not checked against current local product information. | Safety summary withheld — check official label Unverified catalogue summary (Catalogue warning level) for Trintellix in US; not checked against current local product information. |
| Est. TV ad spend | $170M | $130M |
| Side effects and serious risks | — Unverified catalogue summary (Side effects and serious risks) for Rexulti in US; not checked against current local product information. | — Unverified catalogue summary (Side effects and serious risks) for Trintellix in US; not checked against current local product information. |
Trintellix
Sources and editorial standards
Use the current DailyMed labels to verify approved uses, boxed warnings, and side effects for each medication. Label results can differ by product, strength, and formulation.
Page updated November 4, 2026; the linked resources have not necessarily been reviewed on this date.
Frequently asked questions
Is Rexulti or Trintellix better?
This directory does not compare clinical effectiveness or safety. Listing Rexulti and Trintellix together does not establish shared approved indications, equivalence or suitability as substitutes. Consult the correct local labels and your prescriber.
What's the difference between Rexulti and Trintellix?
The table shows catalogue identification and estimated advertising information for Rexulti and Trintellix, not a verified medical comparison. Medical descriptions, mechanisms and safety summaries are withheld.
Which one spends more on TV ads?
Rexulti has the larger estimated TV advertising budget of the two.