Rexulti vs Zoloft
A side-by-side look at two mental health medications advertised on TV. Informational only — not medical advice.
| US Rexulti | US Zoloft | |
|---|---|---|
| Generic name | brexpiprazole | sertraline |
| Drug class | Atypical Antipsychotic | SSRI (Antidepressant) |
| Treats | Major depression (add-on), schizophrenia, agitation in dementia | Depression, anxiety, OCD, PTSD |
| Category | Mental Health | Mental Health |
| Manufacturer | Otsuka/Lundbeck | Pfizer |
| Year approved | 2015 | 1991 |
| FDA warning | Black box warning | Black box warning |
| Est. TV ad spend | $170M | $1M |
| Common side effects | Weight gain, Restlessness, Drowsiness, Movement disorders | Nausea, Sexual problems, Insomnia, Diarrhea |
Frequently asked questions
Is Rexulti or Zoloft better?
Neither is universally "better." Rexulti (brexpiprazole) and Zoloft (sertraline) are both used for mental health, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.
What's the difference between Rexulti and Zoloft?
Rexulti is a Atypical Antipsychotic made by Otsuka/Lundbeck, while Zoloft is a SSRI (Antidepressant) made by Pfizer. See the table above for a side-by-side breakdown.
Which one spends more on TV ads?
Rexulti has the larger estimated TV advertising budget of the two.