Rexulti vs Zoloft
A side-by-side look at two mental health medications advertised on TV. Informational only — not medical advice.
Maintained by TVPills Editorial Team · Site updated November 4, 2026 (not a product-label review)
| Attribute | US Rexulti | US Zoloft |
|---|---|---|
| Generic name | brexpiprazole Unverified catalogue summary (Generic name) for Rexulti in US; not checked against current local product information. | sertraline Unverified catalogue summary (Generic name) for Zoloft in US; not checked against current local product information. |
| Drug class | See official local label Unverified catalogue summary (Drug class) for Rexulti in US; not checked against current local product information. | See official local label Unverified catalogue summary (Drug class) for Zoloft in US; not checked against current local product information. |
| Treats | Adult major depression (add-on), schizophrenia (age 13+), agitation associated with dementia due to Alzheimer's disease Unverified catalogue summary (Treats) for Rexulti in US; not checked against current local product information. | Major depression, OCD, panic disorder, PTSD, social anxiety disorder, PMDD Unverified catalogue summary (Treats) for Zoloft in US; not checked against current local product information. |
| Category | Mental Health Unverified catalogue summary (Category) for Rexulti in US; not checked against current local product information. | Mental Health Unverified catalogue summary (Category) for Zoloft in US; not checked against current local product information. |
| Manufacturer | Otsuka Pharmaceutical Co., Ltd. Unverified catalogue summary (Manufacturer) for Rexulti in US; not checked against current local product information. | Viatris Specialty LLC (US distributor) Unverified catalogue summary (Manufacturer) for Zoloft in US; not checked against current local product information. |
| Year approved | — Unverified catalogue summary (Year approved) for Rexulti in US; not checked against current local product information. | — Unverified catalogue summary (Year approved) for Zoloft in US; not checked against current local product information. |
| Catalogue warning level | Safety summary withheld — check official label Unverified catalogue summary (Catalogue warning level) for Rexulti in US; not checked against current local product information. | Safety summary withheld — check official label Unverified catalogue summary (Catalogue warning level) for Zoloft in US; not checked against current local product information. |
| Est. TV ad spend | $170M | $1M |
| Side effects and serious risks | — Unverified catalogue summary (Side effects and serious risks) for Rexulti in US; not checked against current local product information. | — Unverified catalogue summary (Side effects and serious risks) for Zoloft in US; not checked against current local product information. |
Sources and editorial standards
Use the current DailyMed labels to verify approved uses, boxed warnings, and side effects for each medication. Label results can differ by product, strength, and formulation.
Page updated November 4, 2026; the linked resources have not necessarily been reviewed on this date.
Frequently asked questions
Is Rexulti or Zoloft better?
This directory does not compare clinical effectiveness or safety. Listing Rexulti and Zoloft together does not establish shared approved indications, equivalence or suitability as substitutes. Consult the correct local labels and your prescriber.
What's the difference between Rexulti and Zoloft?
The table shows catalogue identification and estimated advertising information for Rexulti and Zoloft, not a verified medical comparison. Medical descriptions, mechanisms and safety summaries are withheld.
Which one spends more on TV ads?
Rexulti has the larger estimated TV advertising budget of the two.