Linzess Alternatives
Drugs like Linzess (linaclotide) — other gastrointestinal medications advertised on TV that may be alternatives. Informational only — not medical advice. Only your doctor can decide what's right for you.
Rezdiffra
resmetirom · Madrigal Pharmaceuticals
Treats Metabolic dysfunction-associated steatohepatitis (MASH)
Trulance
plecanatide · Salix (Bausch Health)
Treats Chronic constipation and IBS-C
Ibsrela
tenapanor · Ardelyx
Treats Irritable bowel syndrome with constipation (IBS-C)
Frequently asked questions
What drugs are similar to Linzess?
Drugs like Linzess include other gastrointestinal medications advertised on TV such as Rezdiffra, Trulance, Ibsrela and more. They treat similar conditions but can differ in how they work, dosing, side effects and cost — your doctor can tell you which is the closest match for you.
What can I take instead of Linzess?
Other gastrointestinal medications advertised on TV include Rezdiffra, Trulance, Ibsrela and others. The right alternative depends on your diagnosis, medical history and insurance — only your doctor can recommend a substitute for Linzess. This page is informational only.
Is there a generic version of Linzess?
Linzess is sold as linaclotide. Whether a lower-cost generic is available depends on patent status — ask your pharmacist, and see the cost & savings page for ways to pay less.
Are these alternatives the same as Linzess?
No. These are different gastrointestinal medications used for similar conditions. They can differ in active ingredient, how they work, dosing, side effects and cost. Use the side-by-side comparisons to see the differences, and never switch medications without medical advice.