Entresto Side Effects
Common and serious side effects of Entresto (sacubitril/valsartan), what to watch for, and when to call your doctor.
FDA Boxed Warning
Entresto carries the FDA's most serious safety warning. Review the full prescribing information and discuss the risks with your doctor.
Common side effects
This is not a complete list. Always consult a doctor or pharmacist.
- Low blood pressure
- High potassium
- Kidney problems
- Dizziness
- Cough
- Harm to a fetus
Serious warnings
Entresto carries an FDA Boxed Warning — the agency's most serious safety alert. Read the full prescribing information and talk to your doctor about the risks before starting or changing treatment.
When to call a doctor
As a general rule with any prescription medicine, contact your doctor about any side effect that is severe, persistent, or worries you. General guidance is to seek emergency care for signs of a serious allergic reaction to any medicine — such as trouble breathing or swelling of the face, lips, tongue, or throat.
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Frequently asked questions
What are the most common side effects of Entresto?
Commonly reported side effects of Entresto (sacubitril/valsartan) include Low blood pressure, High potassium, Kidney problems, Dizziness, Cough, and Harm to a fetus. This is not a complete list — tell your doctor or pharmacist about any side effects you experience.
Does Entresto have any serious or boxed warnings?
Entresto carries an FDA Boxed Warning — the agency's most serious safety alert. Read the full prescribing information and talk to your doctor about the risks before starting or changing treatment.
When should I call my doctor about Entresto side effects?
As a general rule with any prescription medicine, call your doctor about any side effect that is severe, doesn't go away, or worries you. General guidance is to seek emergency care for signs of a serious allergic reaction to any medicine — such as trouble breathing or swelling of the face, lips, tongue, or throat. For advice about your situation, talk to a licensed healthcare provider.
Where can I find the full list of Entresto side effects?
The side effects above are commonly reported ones recorded for Entresto (sacubitril/valsartan); they are not a complete list. For the full prescribing information and medication guide, check the official Entresto label or ask your doctor or pharmacist.
Should I stop taking Entresto if I have side effects?
General medical guidance is not to stop a prescription medicine on your own without talking to your doctor first. Your doctor can advise whether to continue, adjust, or change your treatment. This page is informational and not medical advice.