Nuplazid Side Effects
Common and serious side effects of Nuplazid (pimavanserin), what to watch for, and when to call your doctor.
FDA Boxed Warning
Nuplazid carries the FDA's most serious safety warning. Review the full prescribing information and discuss the risks with your doctor.
Common side effects
This is not a complete list. Always consult a doctor or pharmacist.
- Increased mortality in elderly dementia patients
- Swelling
- Nausea
- Confusion
- Irregular heartbeat (QT prolongation)
Serious warnings
Nuplazid carries an FDA Boxed Warning — the agency's most serious safety alert. Read the full prescribing information and talk to your doctor about the risks before starting or changing treatment.
When to call a doctor
As a general rule with any prescription medicine, contact your doctor about any side effect that is severe, persistent, or worries you. General guidance is to seek emergency care for signs of a serious allergic reaction to any medicine — such as trouble breathing or swelling of the face, lips, tongue, or throat.
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Frequently asked questions
What are the most common side effects of Nuplazid?
Commonly reported side effects of Nuplazid (pimavanserin) include Increased mortality in elderly dementia patients, Swelling, Nausea, Confusion, and Irregular heartbeat (QT prolongation). This is not a complete list — tell your doctor or pharmacist about any side effects you experience.
Does Nuplazid have any serious or boxed warnings?
Nuplazid carries an FDA Boxed Warning — the agency's most serious safety alert. Read the full prescribing information and talk to your doctor about the risks before starting or changing treatment.
When should I call my doctor about Nuplazid side effects?
As a general rule with any prescription medicine, call your doctor about any side effect that is severe, doesn't go away, or worries you. General guidance is to seek emergency care for signs of a serious allergic reaction to any medicine — such as trouble breathing or swelling of the face, lips, tongue, or throat. For advice about your situation, talk to a licensed healthcare provider.
Where can I find the full list of Nuplazid side effects?
The side effects above are commonly reported ones recorded for Nuplazid (pimavanserin); they are not a complete list. For the full prescribing information and medication guide, check the official Nuplazid label or ask your doctor or pharmacist.
Should I stop taking Nuplazid if I have side effects?
General medical guidance is not to stop a prescription medicine on your own without talking to your doctor first. Your doctor can advise whether to continue, adjust, or change your treatment. This page is informational and not medical advice.